Aim: Acute appendicitis is the most common cause of abdominal surgical emergencies.Early diagnosis of appendicitis can reduce perforation and mortality rate.High-mobility group box 1 (HMGB1) protein has been identified as a pro-inflammatory factor and its elevated serum levels have been noted in different diseases.So, the aim lock shock and barrel
Episodes of inflammation and pain are predominant features of arthritic joint diseases.Drug delivery systems (DDS) could reduce inflammation and pain long-term without chances of infection upon multiple injections.To allow for long-term evaluation of DDS, we modified a previously published acute arthritis model by extending follow-up periods betwee
ABSTRACT High-throughput amplicon sequencing is a critical tool for studying microbiota; however, it results only in relative abundance data.Thus, changes in absolute abundance of microbiota cannot be determined, which hinders further microbiology research.We have therefore established a gradient internal standard absolute quantification (GIS-AQ) v
IntroductionGlobally, 11 million children have died before reaching their fifth birthday.The introduction of the Integrated Management of Newborn and Childhood Illness (IMNCI) protocol reduces the morbidity and mortality rates among children under the age of 5.However, the share of neonatal mortality is increasing.As a result, the United Nations ha
Abstract Background Astrocytes (AC) are essential for brain homeostasis.Much data suggests that AC support and protect the vascular endothelium, but increasing evidence indicates that during injury conditions they may lose their supportive role resulting in endothelial read more cell activation and BBB disturbance.Understanding the triggers that fl